BPC-157 (Body Protection Compound-157)
BPC-157 is a synthetic pentadecapeptide (15 amino acids) derived from a naturally occurring Body Protection Compound found in human gastric juice. It exhibits broad cytoprotective, angiogenic, and tissue-regenerative properties, influencing diverse molecular pathways involved in cell survival, wound healing, and inflammation resolution.
Mechanistic Overview:
BPC-157 promotes angiogenesis and tissue repair by upregulating vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF-β) signaling pathways. It enhances fibroblast proliferation, collagen formation, and epithelial regeneration through activation of focal adhesion kinase (FAK) and paxillin—key mediators of cell migration and cytoskeletal reorganization.
The peptide also modulates the nitric oxide (NO) pathway, improving microvascular circulation, tissue oxygenation, and endothelial function, while attenuating oxidative stress and inflammatory cytokine activity (including TNF-α, IL-1β, and IL-6). Additionally, BPC-157 exhibits neuroprotective properties and stabilizes the gut–brain axis, contributing to mucosal and systemic protection in stress-related injury models.
Biological Effects:
Accelerates muscle, tendon, and ligament healing
Stimulates angiogenesis and collagen synthesis
Reduces inflammation and oxidative damage
Supports gastrointestinal mucosal repair and neuroprotection
Enhances cell migration, vascular regeneration, and wound closure
Applications:
Research on soft tissue regeneration and vascular biology
Studies of inflammatory modulation and cytoprotective mechanisms
Investigations into musculoskeletal recovery, gut healing, and neural repair
Chemical Information:
Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Molecular Formula: C₆₂H₉₈N₁₆O₂₂
Molecular Weight: ~1419.5 Da
Purity: ≥98% (HPLC)
Form: Lyophilized powder
Storage: Store at –20°C; reconstituted solution stable at 2–8°C for up to 7 days
For Research Use Only. Not for human consumption.